Best Weight Loss Medications in 2025
Compare 2025's top GLP-1 weight-loss ranked by cost, support, and real results.
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4.7 / 5
Remedy Meds — All-Inclusive GLP-1 Care
- Unlimited telehealth visits
- No insurance or hidden fees
Remedy Meds — All-Inclusive GLP-1 Care
- Unlimited telehealth visits
- No insurance or hidden fees
- Whole-person support
4.7 / 5
Outstanding
4.6 / 5
Ro Body — Insurance-Supported GLP-1 Weight Loss
- Wide range of medication options
- Personalized coaching & diagnostics
Ro Body — Insurance-Supported GLP-1 Weight Loss
- Wide range of medication options
- Personalized coaching & diagnostics
- Hands-on insurance navigation
4.6 / 5
Exceptional
4.3 / 5
Sprout Health — Effortless, Affordable GLP-1 Results
- Straightforward pricing
- No subscriptions
Sprout Health — Effortless, Affordable GLP-1 Results
- Straightforward pricing
- No subscriptions
- Fast nationwide shipping
4.3 / 5
Affordable Plans
4.2 / 5
MEDVi — 24/7 Support & Fast GLP-1 Delivery
- Fast home delivery
- 24/7 medical chat
MEDVi — 24/7 Support & Fast GLP-1 Delivery
- Fast home delivery
- 24/7 medical chat
- Spring promo: Save $120
4.2 / 5
Personalized Care
4.2 / 5
Mochi — Doctor-Guided Tailored Weight Loss
- Nutrition & lifestyle coaching
- 50-state availability
Mochi — Doctor-Guided Tailored Weight Loss
- Nutrition & lifestyle coaching
- 50-state availability
- Start for $79/mo
4.2 / 5
Excellent
4.1 / 5
Fridays — All-In-One Holistic GLP-1 Program
- Coaching & community support
- Starts at $99/mo
Fridays — All-In-One Holistic GLP-1 Program
- Coaching & community support
- Starts at $99/mo
- Available nationwide
4.1 / 5
Top for Community Support
What Our Users Say
Their process is flawless! I get check ins on a timely basis. Maybe a little slow but still within the SLA of up to 3 days. Very clear instructions. I found the medicine worked right away especially as I titrated up from 2.5 to 10.
— Edythe J.
Straight to the point no nonsense, no gimmicks. Did the questionnaire, had an appt next day, called come support and expect my script to come in 3-5 days. So far very good experience.
— Lee C.
Communication is timely and accurate. Procedure is simple and easy to understand. Medication is ordered and delivered on time, and is working.
— Joseph L.
How GLP-1 Medications Promote Weight Loss
GLP-1 receptor agonists slow stomach emptying, reduce hunger hormones, and improve insulin signalling. Studies show average losses of 15–20 % body weight over 12–18 months when combined with healthy habits.
Brand-Name vs. Compounded Options
Brand drugs like Wegovy®, Ozempic®, and Zepbound™ can exceed $1000/month retail. Compounded semaglutide or tirzepatide from licensed 503A/503B pharmacies typically cost $150–$250, though potency and insurance coverage vary.
Who Qualifies for a Prescription?
Most providers require a BMI ≥ 30 —or ≥ 27 with weight-related conditions such as hypertension or type 2 diabetes—and no history of medullary thyroid carcinoma or pancreatitis.
Medical Disclaimer
Information is educational only and not a substitute for professional medical advice. Consult with a healthcare professional for any medical concerns.